ARS researchers examine immune-cell populations in an archival laboratory photograph

Pig immune-cell atlas maps nearly 50,000 cells

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A 2026 study assembled an open atlas of immune cells from four pig lymphoid tissues.

ARS researchers examine immune-cell populations in an archival laboratory photograph
USDA ARS archive, K7070-7. Photo by Keith Weller; this is not the 2026 atlas study.

Cells from four tissues

USDA Agricultural Research Service and university researchers used single-cell RNA sequencing to study pig immune cells from bone marrow, thymus, lymph nodes and spleen. The team identified nearly 50,000 cells. Their paper appeared in Frontiers in Immunology on 4 March 2026.

An open research atlas

The investigators compared cell populations across tissues and built an online application for searching gene-expression patterns. They reported that several immune-cell groups differed by tissue, while some shared features with human immune cells. The atlas provides a research dataset rather than a vaccine or a new farm treatment.

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